A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids
نویسندگان
چکیده
منابع مشابه
G-Quadruplex Nucleic Acids
1 IRB Barcelona, IQAC-CSIC, Jordi Girona 16-26, 08034 Barcelona, Spain 2 2 INSERM U869, Laboratoire ARNA, Université de Bordeaux 2, Institut Européen de Chimie-Biologie, 2 rue Robert Escarpit, 33607 Pessac Cedex, France 3Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II”, I-80126 Naples, Italy 4 Faculty of Mechanical Engineering, University of Maribor,...
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Since the discovery of self-cleavage and ligation activity of the group I intron, the expansion of research interest in catalytic nucleic acids has provided a valuable nonprotein resource for manipulating biomolecules. Although a multitude of reactions can be enhanced by this class of catalyst, including trans-splicing activity of the group I intron (which could be applied to gene correction), ...
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G-quadruplexes constitute a class of nucleic acid structures defined by stacked guanine tetrads (or G-tetrads) with guanine bases from neighboring tetrads stacking with one another within the G-tetrad core. Individual G-quadruplexes can also stack with one another at their G-tetrad interface leading to higher-order structures as observed in telomeric repeat-containing DNA and RNA. In this study...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2018
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.8b05337